亚急性失语恢复与语言网络内外的休息状态连接有关
Melissa D Stockbridge1, Andreia V Faria2, Julius Fridriksson3
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.
Annals of clinical and translational neurology
|July 5, 2023
概括
在中风患者中,阿法西亚治疗改善了大脑连接. 与低响应者相比,高响应者在语言网络中显示出更大的连接性变化,这表明有针对性的治疗有好处.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音和语言病理学 语言病理学
背景情况:
- 失言症是中风的常见后果,影响沟通能力.
- 了解中风后大脑连接的变化以及治疗后的恢复至关重要.
- 脑中风后的亚急性期是神经重组的关键窗口.
研究的目的:
- 为了研究在中风后三个月内治疗失言症后大脑功能连接的变化.
- 为了比较那些对治疗反应良好的人与那些没有反应的人之间的连接性变化.
主要方法:
- 20名患有亚急性失语症的人在15小时的语言治疗之前和之后接受了MRI扫描.
- 参与者根据名词命名测试的改进被分为高或低响应者.
- 休息状态功能连接性分析的重点是左侧状环及其与关键语言区域的连接.
主要成果:
- 左状回旋和语言网络之间的基线连接在高响应者和低响应者之间是可比的.
- 与低响应者相比,高响应者表现出左侧状回环和几个语言网络区域 (例如,三角体,上状回环) 之间的连接性显著增加.
- 这些连接性变化发生在两半球的ipsilateral和 contralateral.
结论:
- 在亚急性阶段治疗失言症可以显著恢复近接语言网络连接.
- 观察到的抵押品连接性变化可能表明补偿性重组,这是过渡性恢复期的特征.
- 这些发现突出了针对性语言疗法的潜力,以驱动神经可塑性并改善中风后的沟通结果.
相关概念视频
01:10Higher Mental Functions of the Brain: Language
928
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
928
01:27Language and Cognition
376
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
376
01:35Long-term Potentiation
55.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.4K