在体外模型作为研究肠道微生物群在肥胖中的作用的工具
Abigail González1, Eva Conceição2, José António Teixeira1,3
1CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal.
Critical reviews in food science and nutrition
|July 5, 2023
概括
实验室模型表明,用益生菌和食物化合物调节肠道微生物群可以帮助控制肥胖. 这些模型揭示了健康的肠道微生物群如何帮助体重管理和代谢健康.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 肥胖是一个全球性健康问题,与肠道微生物失衡 (失调) 有关.
- 在体内模型是有用的,但面临道德和实际的局限性.
- 在体外模型为研究肠道微生物群和肥胖提供了一个有希望的替代方案.
研究的目的:
- 审查关于肠道微生物群对肥胖的调节的体外发现.
- 讨论在肥胖中微生物群,饮食和宿主新陈代谢之间的相互作用.
- 评估目前用于肥胖研究的体外结肠模型.
主要方法:
- 对益生菌和食品化合物的体外研究的审查.
- 批量和动态发酵系统的讨论.
- 对微生物群与宿主相互作用的体外模型的分析.
主要成果:
- 实验室模型证明了肠道微生物群在体重管理中的作用.
- 恒温微生物群可以产生和神经递质和代谢物.
- 微生物群调节保护肠道屏障,改善脂肪组织代谢.
结论:
- 在体外模型是肥胖研究的宝贵工具.
- 准肠道微生物群显示出对肥胖治疗的潜力.
- 这些模型可能会导致肥胖相关疾病的新疗法.
相关概念视频
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...