通过药物重新定位和输送系统的帮助,增强抗癌免疫反应
Zile Fu1, Xiaoming Zhang2, Yanfeng Gao3
1Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Clinical and translational medicine
|July 5, 2023
概括
本综述探讨了重用药物和先进的输送系统,以增强抗癌免疫力. 这些策略旨在改善免疫识别,激活,透和瘤杀死,以获得更好的癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫系统对癌症的发展和进展至关重要.
- 免疫调节疗法,如抗PD-1/PD-L1抗体,已经在癌症治疗中取得了进步.
- 重新利用现有药物和新的输送系统是癌症免疫治疗中的新兴策略.
研究的目的:
- 系统地审查那些增强抗癌免疫反应的药物和输送系统.
- 探索改善免疫识别,激活,透和杀死瘤的策略.
- 讨论癌症免疫疗法的当前挑战和未来方向.
主要方法:
- 对癌症免疫疗法重用药物的系统性文献综述.
- 在瘤免疫学中分析新型药物输送系统.
- 讨论癌症免疫调节的作用机制.
主要成果:
- 识别了具有潜在的重新用途以提高抗癌免疫力的传统和新兴药物.
- 突出了瘤免疫学中新型治疗策略的药物输送系统的进展.
- 详细介绍了释放抗癌反应的各种方面,包括免疫识别,激活,透和瘤杀死.
结论:
- 重新设计的药物和先进的输送系统为增强抗癌免疫提供了有希望的途径.
- 这些策略可以调节对抗癌症免疫反应的关键方面.
- 需要进一步的研究来解决目前的警告,并优化未来的治疗方向.
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