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相关概念视频

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

248
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
248
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

847
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
847
Atomic Nuclei: Nuclear Relaxation Processes01:23

Atomic Nuclei: Nuclear Relaxation Processes

683
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis,  the precessing magnetic moments are randomly oriented around the z-axis.
683
Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

750
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
750
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

408
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
408
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.1K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.1K

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相关实验视频

Updated: Jul 24, 2025

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
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通过双脉冲相调节的动态核极化.

Venkata SubbaRao Redrouthu1, Sanjay Vinod-Kumar1, Guinevere Mathies1

  • 1Department of Chemistry, University of Konstanz, Universitätsstrasse 10, 78464 Konstanz, Germany.

The Journal of chemical physics
|July 5, 2023
PubMed
概括
此摘要是机器生成的。

新的双脉冲相调制 (TPPM) 动态核极化 (DNP) 增强了固态NMR的灵敏度. 这种方法有望改善大量核的极化,为未来的DNP序列开发提供了有价值的参考.

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Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
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科学领域:

  • 固态核磁共振 (NMR) 是一种技术.
  • 量子信息科学 量子信息科学
  • 材料科学 材料科学 材料科学

背景情况:

  • 动态核极化 (DNP) 通过将电子自旋极化转移到原子核上来增强NMR灵敏度.
  • 开发大量核的有效DNP脉冲序列至关重要,但不完整.
  • 了解管理DNP序列性能的原则对于进步至关重要.

研究的目的:

  • 介绍并从理论上描述一个新的DNP脉冲序列,双脉冲相调节 (TPPM) DNP.
  • 在提高灵敏度和操作参数方面,比较TPPM DNP与现有序列 (XiX和TOP) 的性能.
  • 调查影响DNP序列性能的因素,如结核频率和极化剂度.

主要方法:

  • 使用周期性DNP脉冲序列的电子-质子极化转移的理论描述.
  • 数字模拟用于验证理论模型.
  • 在1.2特斯拉进行实验验证,测量不同度频率的灵敏度增益和性能.
  • 对偏振剂度对DNP序列效率的影响分析.

主要成果:

  • 与XiX和TOP DNP相比,TPPM DNP在高节点频率下显示出更高的灵敏度增益.
  • 即使在低频率 (7 MHz) 中,XiX序列也表现出强大的性能.
  • 快速的电子-质子极化转移,与保存的二极合相关,与快速的DNP积累相关.
  • XiX和TOP DNP序列对偏振剂度的变化表现出不同的反应.

结论:

  • TPPM DNP是增强固态NMR灵敏性的一个有希望的序列.
  • DNP序列的性能高度依赖于结核频率和极化剂度.
  • 理论和实验洞察力为设计高级DNP序列提供了关键的基准.