早期的六分钟步行测试可能预测冠状动脉旁路移植后的中期结果
Hayanne O Pauletti1, Walter José Gomes1,2, Isadora S Rocco1
1Programa de Pós-Graduação em Cardiologia, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
Brazilian journal of cardiovascular surgery
|July 5, 2023
概括
冠状动脉旁路移植 (CABG) 后6分钟步行距离 (6MWD) 减少34.6%,预测中期结果不佳. 心肺绕道和启发性肌肉强度的影响6MWD下降.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 康复医学 康复医学 康复医学
背景情况:
- 冠状动脉旁路移植 (CABG) 是一种主要的心脏手术.
- 评估患者的康复和预测CABG后的临床结果对于有效的管理至关重要.
- 六分钟步行距离 (6MWD) 是一种常见的功能测试,但其在CABG后早期的预后价值需要进一步调查.
研究的目的:
- 评估6分钟步行距离 (6MWD) 作为冠状动脉旁路移植 (CABG) 后中期临床结果 (3个月) 的预后标记.
- 为了确定6MWD在早期术后期显著下降的预测因素.
- 确定从基线到术后5日6MWD的百分比下降率.
主要方法:
- 一项前性队列研究包括接受选择性CABG的患者.
- 6MWD的百分比下降是通过比较术前值和术后第5天 (POD5) 的值来计算的.
- 临床结果在出院3个月后进行评估;统计分析包括线性回归和ROC曲线分析.
主要成果:
- 与手术前值相比,POD5 (32.5±16.5%下降,P<0.0001) 观察到6MWD显著下降.
- 心肺绕道 (CPB) 使用和较低的手术前呼吸肌肉强度是6MWD中较大百分比下降的独立预测因素.
- 在POD5的6MWD中,34.6%的百分比下降是预测3个月后更差的临床结果的最佳切线 (AUC=0.82,灵敏度=78.95%,特异性=76.19%).
结论:
- 术后6MWD的百分比下降超过POD5的34.6%,可以预测CABG后3个月的不良临床结果.
- 手术后的6MWD下降与CPB使用和手术前的呼吸肌肉强度独立相关.
- 这些发现支持6MWD对监测康复的临床实用性,并表明早期,住院预防策略的潜力,以优化患者管理.
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