在囊性纤维化中,肠道微生物组在生命早期的发展
Courtney E Price1, Thomas H Hampton1, Rebecca A Valls1
1Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.
mSphere
|July 5, 2023
概括
患有囊性纤维化 (CF) 的儿童的肠道微生物群随着时间的推移而发展,早期的失生症迹象可能与以后的肠道健康和肺部感染有关. 这项研究追踪了从出生到4岁的微生物组变化.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 囊性纤维化 (CF) 是一种影响粘液产生的遗传性疾病,导致慢性肺部感染和胃肠道问题.
- 在CF中,肠道微生物组失调被认可,但从出生开始的纵向发育不太清楚.
- 早期生命是肠道微生物组和免疫系统发育的关键窗口.
研究的目的:
- 从出生到四岁的CF儿童的肠道微生物组发展的纵向特征.
- 为了确定CF肠道微生物群和特定种群中的与年龄相关的变化.
- 探索早期肠道失调症,CF肺病类型,以及与炎症性肠病标志物的潜在联系之间的关系.
主要方法:
- 来自CF (cwCF) 儿童队列的便样本的16S rRNA基因扩增序列测序.
- 从出生到幼儿 (0-4岁) 的肠道微生物组组成和多样性的纵向分析.
- 应用克罗恩氏失生症指数来评估失生症模式.
主要成果:
- 肠道微生物组的α多样性随着年龄的增长而增加,在cwCF中稳定在两年左右.
- 特定的种群如Akkermansia随着年龄的增长而减少,Blautia随着年龄的增长而增加.
- 与CF肺部疾病相关的几种种类持续存在,这表明潜在的肠到肺部播种.
- 早期高克罗恩病相关的失生症与儿童时期晚些时候较低的 * 细菌体 * 丰度相关.
结论:
- 患有CF的儿童的肠道微生物组在生命早期经历了重大变化.
- 早期肠道失生症标志物可能预测 cwCF.后来的微生物组合.
- 肠道微生物组可以作为呼吸道病原体的储存库,并表明早期炎症性肠道疾病的变化.
相关概念视频
Anatomy of the Intestines
72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
Cystic Fibrosis: Pathogenesis
293
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
293
Bacterial Flora of the Large Intestine
528
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
528
Cystic Fibrosis: Management
195
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
195
Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K


