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Updated: Jul 24, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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获得的二次HER2突变增强HER2/MAPK信号传递并促进对乳腺癌中HER2激酶抑制的抵抗

Arnaldo Marín1,2,3, Abdullah Al Mamun4, Hima Patel3

  • 1UT Southwestern Simmons Comprehensive Cancer Center, Dallas, Texas.

Cancer research
|July 5, 2023
PubMed
概括

除了HER2T798I之外的二次HER2突变,在乳腺癌中导致对HER2氨酸激酶抑制剂 (TKI) 的耐药性. 结合HER2和MEK抑制可以克服这种获得的耐药性.

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