在clinicaltrials.gov上注册角膜试验的出版率
Eli K Cehelyk1, Marcos A Crespo2, Zeba A Syed2
1Thomas Jefferson University, Philadelphia, PA; and.
Cornea
|July 5, 2023
概括
角膜临床试验的发表率较低,仅有51.9%的注册研究发表. 这突显了眼科研究中的潜在出版偏见,特别是非行业赞助的试验.
科学领域:
- 眼科医生 眼科 眼科
- 临床研究 临床研究
- 出版道德 出版道德
背景情况:
- 以角膜为中心的临床试验对于推进眼科治疗至关重要.
- 了解出版模式对于评估研究影响和识别潜在偏见至关重要.
研究的目的:
- 描述在2020年之前在ClinicalTrials.gov注册的以角膜为中心的临床试验.
- 为了确定注册试验和同行评审文献之间的出版差异.
主要方法:
- 在clinicaltrials.gov的系统搜索中,确定了在2020年1月1日之前完成的干预角膜试验.
- 通过搜索临床试验.gov,PubMed.gov和谷歌学者.gov来评估出版状况.
- 收集了关于赞助商,干预类型,阶段,干眼焦点和研究人员位置的数据.
主要成果:
- 在520项试验中,51.9%的结果已公布.
- 在美国,行业赞助商主要为干眼药物试验提供资金.
- 非行业赞助商专注于设备和程序试验,其出版率较高 (64.2%).
- 非行业,后期阶段和程序试验显示了显著更高的出版率.
结论:
- 对于基于角膜的临床试验,存在很大的出版差距,超过48%的临床试验仍未发表.
- 发表率因赞助商和干预类型而异,这表明研究结果的传播可能存在偏见.
- 对影响出版的因素进行进一步调查是有必要的,以确保眼科医学的全面科学知识.
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