通过益生菌乳球菌抑制与毒性休克综合征相关的黄金葡萄球菌
Patrick M Schlievert1, Adriana V Gaitán2, Samuel H Kilgore1
1Department of Microbiology and Immunology, University of Iowa; Carver College of Medicine, Iowa City, Iowa, USA.
Microbiology spectrum
|July 5, 2023
概括
益生菌乳酸菌显示出对抗毒性休克综合征 (TSS) 的潜力. 乳杆菌酸性菌类抑制了金黄色葡萄球菌的生长和毒素的产生,而乳杆菌酸性菌类减少了毒素水平,这表明益生菌在预防粘膜感染方面发挥了作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 益生菌 益生菌 益生菌
背景情况:
- 黄金葡萄球菌,特别是USA200克隆群,经常殖民粘膜表面.
- 这种病原体产生毒性冲击综合征毒素-1 (TSST-1),这是TSS的一个关键因素,通常来自阴道或胃肠道.
- TSST-1可以在人类阴道上皮细胞 (HVEC) 中触发促炎反应.
研究的目的:
- 评估乳杆菌酸性菌LA-14和乳杆菌酸性菌Rhamnosus HN001对TSST-1产生的S. aureus的疗效.
- 评估这些乳酸菌对TSST-1产生的影响及其对HVECs的炎症影响.
- 确定这些益生菌在预防粘膜相关TSS方面的潜力.
主要方法:
- 进行了竞争生长实验,以评估乳酸菌对S. aureus生长和TSST-1生产的抑制.
- 测量了TSST-1在HVEC中诱导化学激素 (互乐金-8) 生产的能力.
- 分析了单独和与TSST-1结合的乳酸菌对HVEC化学基因产生的影响.
主要成果:
- Lacticaseibacillus rhamnosus HN001抑制了TSST-1的产生,部分原因是中等酸化,但没有影响S. aureus的生长.
- 乳杆菌酸性菌种LA-14表现出对S. aureus的杀菌活性,并抑制了TSST-1的产生,归因于酸化,H2O2和其他抗菌因素.
- 乳酸菌都没有在HVEC中诱导显著的化学产量,并且两者都减轻了TSST-1-诱导的化学释放.
结论:
- 乳杆菌酸性LA-14在控制金黄色菌和TSST-1方面显示出显著的潜力.
- Lacticaseibacillus rhamnosus HN001通过减少TSST-1产量提供了一个补充方法.
- 这些益生菌乳杆菌可以作为一种策略,以减少粘膜相关的TSS的发生率,包括月经TSS和肠球炎相关的TSS.
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