胡巴华根片改善糖尿病病中的功能:一个现实世界的回顾性队列研究
Ying Tan1,2, Ruihan Li1,2, Peipei Zhou1,2
1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in endocrinology
|July 5, 2023
概括
与HKC单独相比,Huobahuagen片 (HBT) 与Huangkui囊 (HKC) 治疗相结合,在糖尿病病 (DKD) 患者中显著改善了功能. 这种组合疗法在控制DKD进展方面表现出有利的安全性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症,导致功能逐渐下降.
- 目前对DKD的治疗有局限性,需要探索新的治疗策略.
- 华宝药片 (HBT) 是一种传统中医药,因其潜在的脏保护作用而受到研究.
研究的目的:
- 评估Huobahuagen片 (HBT) 在糖尿病病 (DKD) 患者改善功能方面的疗效.
- 为了比较结合HBT和Huangkui囊 (HKC) 治疗与DKD患者的HKC单一治疗的治疗价值.
- 评估HBT+HKC治疗在现实临床实践中的长期影响和安全性.
主要方法:
- 一个单一中心,回顾性,现实世界的研究,涉及122名DKD患者.
- 患者接受HBT+HKC治疗或单独接受HKC治疗.
- 主要结局包括估计的球过率 (eGFR) 和12个月的eGFR (ΔeGFR) 变化,使用倾向得分匹配和治疗权重的逆概率进行分析.
主要成果:
- 与单独使用HKC组相比,HBT + HKC组在6,9和12个月后显示出显著更高的eGFR (p <0.05).
- 在6个月和12个月的HBT + HKC组中,ΔeGFR显著增加 (p < 0.05).
- 尿白蛋白/肌素比率变化没有显著差异;两组的不良事件发生率都很低.
结论:
- 与单独使用HKC相比,联合HBT+HKC疗法在改善和保护DKD患者的功能方面表现出更高的疗效.
- HBT + HKC 疗法在管理 DKD 方面表现出有利的安全性.
- 建议进一步进行大规模前性随机对照试验,以验证这些发现.
更多相关视频
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
613
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
223
相关概念视频
01:16Antihypertensive Drugs: Action of Diuretics
818
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
818
01:11Renal Failure: Dose Adjustments
123
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
123
01:22Heart Failure Drugs: Diuretics
424
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
424
01:28Chronic Kidney Disease III: Interprofessional Care
45
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
45
01:28Renal Drug Excretion: Tubular Secretion
229
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
229
01:17Factors Affecting Renal Clearance: Renal Impairment
123
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
123