- - 甘氨酸化物:在有机合成中新兴的性合成子
Sandeep Kumar1, Vinod Khatri1,2, Priyanka Mangla1
1Bioorganic Laboratory, Department of Chemistry, University of Delhi Delhi India ashokenzyme@gmail.com virparmar@gmail.com.
RSC advances
|July 5, 2023
概括
本综述总结了C-glycopyranosyl化物和C-glycoconjugates的合成方法,这些分子是重要的生物活性分子. 它涵盖了45年的文献,突出了关键的中间体和合成它们的反应.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 合成化学 合成化学
背景情况:
- C-糖化物是具有显著生物活性的稳定药.
- 合成C-glycopyranosyl化物及其衍生C-glycoconjugates存在化学挑战.
- 这些化合物在药物发现和开发中具有价值.
研究的目的:
- 为C-glycopyranosyl化物和C-glycoconjugates提供综合工艺的综合概述.
- 审查从1979年到2023年的关于这些重要分子合成的文献.
- 为了分类合成方法和形成的C-葡萄糖结合物的类型.
主要方法:
- 使用七个关键中间体来合成C-glycopyranosyl化物:艾伦,提亚,迪,化物,烯和甲.
- 采用了多种反应来整合C-糖合物:核友性添加/替代,还原,凝结,氧化,循环凝结,合和维蒂格反应.
- 基于方法和C-glycoconjugates的性质对合成方法进行分类.
主要成果:
- 已经开发出大量的C-glycopyranosyl化物和C-glycoconjugates的合成过程.
- 关键的中间体和反应类型促进了这些复杂分子的构建.
- 这篇综述涵盖了从1979年到2023年的重要研究时期.
结论:
- 通过多样化和成熟的合成路径,可以获得C-glycopyranosyl化物和C-glycoconjugates.
- 审查的方法为合成这些生物活性化合物的化学家提供了有价值的工具.
- 这项工作提供了对该领域的结构化概述,有助于未来的研究和开发.
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