表面扩散系数和T2*映射在正常和退行性腰椎椎间盘的3TMRI上
Reetika Kapoor1, Varsha Purushottam Rangankar1, Divyajat Kumar1
1Department of Radiodiagnosis, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.
Polish journal of radiology
|July 5, 2023
概括
扩散加权成像 (DWI) 和T2*映射准确地评估腰椎退行性磁盘疾病 (LDDD). 核脉 (NP) 中明显扩散系数 (ADC) 和T2* 值的降低表明早期的LDDD.
科学领域:
- 放射学和成像学 放射学和成像学
- 生物医学工程 生物医学工程
- 整形外科 整形外科 整形外科
背景情况:
- 腰椎退行性磁盘疾病 (LDDD) 是腰部疼痛的一个重要原因.
- 当前的分级系统,如修改后的Pfirrmann分级 (MPG),依赖于主观的视觉评估.
- 需要客观的定量方法来准确评估LDDD.
研究的目的:
- 用表面扩散系数 (ADC) 地图和T2*映射来评估扩散权重成像 (DWI) 的有效性.
- 在腰椎间盘中对核脉 (NP) 和纤维环 (AF) 进行定量分析.
- 将这些定量测量与LDDD修改的Pfirrmann分级 (MPG) 相对应.
主要方法:
- 100名受试者接受了T2加权,DWI与ADC,以及T2*MRI.
- MPG被应用到L3-L4,L4-L5和L5-S1磁盘上.
- 使用感兴趣区域 (ROI) 计算了NP和AF的ADC和T2*值.
主要成果:
- 分析了300个圆盘:68个正常 (I级),232个退化 (II-VIII级).
- 与正常磁盘相比,退化的磁盘在NP,AF和整个磁盘中显示出明显较低的T2*和ADC值.
- 在ADC/T2*值和MPG之间存在显著的负相关性 (p < 0.001). 高精度 (AUC 0.8-0.9) 的LDDD评估.
结论:
- 基于ADC和T2*值的分级尺度为评估LDDD提供了高精度和客观性,超过了视觉MPG.
- 在NP中降低的ADC和T2*值可以作为LDDD的早期生物标志物.
- 这些定量MRI技术提供了一种可靠的方法来评估磁盘退化.
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