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辅助生殖技术不会影响早产儿晚期神经发育结果

Tiphaine Lefebvre^1,2, Cyril Flamant^2,3,4, Marion Olivier⁴

¹Department of Biology and Reproductive Medicine, University Hospital of Nantes, Nantes, France.

Frontiers in pediatrics

|July 5, 2023

概括

辅助生殖技术 (ART) 过早产生的婴儿在4岁时表现出相似或更好的神经发育结果,而不是自然孕育的婴儿. 在这种脆弱人群中,ART并没有对长期神经发育产生负面影响.

科学领域:

新生儿研究新生儿研究
发育儿科发育儿科
生殖医学是一种生殖医学.

背景情况:

辅助生殖技术 (ART) 与早产儿的增加有关.
关于通过ART怀孕的早产婴儿的长期神经发育结果的数据有限.
了解ART对早产婴儿神经发育的影响至关重要.

研究的目的:

为了研究在ART后34周妊娠年龄 (GA) 之前出生的早产婴儿在4岁时的神经发育结果.
为了比较ART怀孕和自然怀孕的早产婴儿之间的神经发育轨迹.
在这个群体中确定与非最佳神经发育相关的因素.

主要方法:

一项队列研究包括166名ART和679名自然受孕的早产婴儿 (出生<34周GA) 在2013-2015年期间.
在4岁时使用年龄和阶段问卷 (ASQ) 评估神经发育和治疗服务的需要.
经社会经济和围产期特征调整后的统计分析.

主要成果:

在ART早产组中,ASQ上至少有两个困难域的风险明显较低 (aOR 0.34,95% CI [0.13-0.88]).
男性性别,低社会经济水平和较低的妊娠年龄 (25-30周) 独立地与非最佳神经发育有关.
在ART和自然受孕组之间,在治疗服务的需要方面没有发现显著差异 (p=0.079).

结论:

通过ART怀孕的早产婴儿在4岁时表现出神经发育结果,与自然怀孕的婴儿相比,甚至更好.
在早产婴儿的长期神经发育方面,ART似乎没有给婴儿带来不利影响.
出生时的妊娠年龄,性别和社会经济地位是早产儿神经发育结果的关键决定因素.

关键词:

辅助生殖技术是一种辅助生殖技术.认知发展认知发展后续行动后续行动在体外受精体外受精.时间过早的早产.

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