Bifidobacterium longum CLA8013对改善肠道排便的作用:一个安慰剂控制的,随机的,双盲研究
Keisuke Okada1, Daisuke Takami1, Yutaka Makizaki1
1R&D Center, Biofermin Pharmaceutical Co., Ltd., 7-3-4 Higashi-machi, Ibukidai, Nishi-ku, Kobe, Hyogo 651-2242, Japan.
Bioscience of microbiota, food and health
|July 5, 2023
概括
热杀死的Bifidobacterium longum CLA8013显著改善了便秘患者的肠道运动. 这种益生菌干预增强了排便频率,便一致性,减少了疲劳和疼痛,没有观察到任何不良影响.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类营养人类营养
背景情况:
- 便秘是一种常见的疾病,影响健康个体,影响生活质量.
- 益生菌,特别是Bifidobacterium菌株,正在被探索,因为它们有可能调节肠道健康.
- 热杀死益生菌为活益生菌提供了替代品,可能具有增强的稳定性和安全性.
研究的目的:
- 评估热杀死的Bifidobacterium longum CLA8013在改善易于便秘的健康个体的肠道运动中的有效性.
- 评估干预对排便频率,便特征和相关症状的影响.
- 为了确定热杀死B. longum CLA8013.的安全性和耐受性.
主要方法:
- 一个安慰剂控制的,随机的,双盲研究设计.
- 包括104名容易便秘的健康个体,随机分为治疗和控制组.
- 每天给 25 亿个殖民地形成单位的热杀死 B. longum CLA8013 或安慰剂,持续 2 周.
主要成果:
- 与安慰剂相比,治疗组的排便频率显著增加.
- 在治疗组中观察到便体积和稳定性的显著改善.
- 在治疗组中减少了劳累,排便时疼痛,改善了生活质量得分.
结论:
- 热杀死的Bifidobacterium longum CLA8013有效地改善了易于便秘的个体的肠道运动.
- 该干预措施显示了良好的安全性,没有报告的不良事件.
- 这种热杀死益生菌菌株显示出作为治疗便秘的治疗选择的希望.
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