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关节骨关节炎的潜在病理和分子机制

Zhang Juan¹, Mu Xing-Tong¹, Zhang Xu^2,3

¹Department of Prosthodontics, Hospital of Stomatology, Tianjin Medical University, Tianjin, PR China.

Journal of dental sciences

|July 5, 2023

概括

关节骨关节炎 (TMJ OA) 是一种复杂的退行性疾病. 本综述详细介绍了其病理变化,分子途径,并强调了对TMJ OA的新诊断和治疗策略的需要.

科学领域:

口腔和牙面部外科手术
类风湿病学类风湿病学
病理学病理学病理学

背景情况:

关节骨关节炎 (TMJ OA) 是一种渐进的退行性疾病.
它不清楚的病因和复杂的机制阻碍了早期诊断和有效的治疗.
TMJ OA对患者和社会经济系统造成了重大负担.

研究的目的:

提供TMJ OA的主要病理变化的叙述性综述.
要总结涉及TMJ OA病变发生的分子信号通路.
确定TMJ OA未来研究和治疗开发的领域.

主要方法:

关于TMJ OA现有研究的文献综述.
综合有关病理特征的信息,包括炎症,ECM退化,细胞行为和血管生成.
分析关键的分子和信号通路参与TMJ OA.

主要成果:

关节OA涉及相互关联的病理变化,形成一个有害的循环.
关键通路如NF-κB,MAPKs和TGF-β信号传递都受到关键影响.
分子和途径的复杂相互作用有助于疾病的挑战性.

结论:

关节OA的特点是不同的病因,复杂的临床表现和治疗结果差.
需要新的in-vivo/in-vitro模型,药物和治疗方法.
进一步阐明遗传因素对于改善诊断和治疗TMJ OA的临床策略至关重要.

关键词:

血管新生的产生.生物行为生物行为细胞外矩阵是细胞外矩阵.炎症炎症是一种炎症.分子路径的分子路径.关节骨关节炎关节骨关节炎

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