在口腔粘膜斑块的临床,组织学和直接免疫光特征有恶性潜在的菌病
Chun-Lei Li1, Xiao-Meng Ren1, Xin Fang1,2
1Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR China.
Journal of dental sciences
|July 5, 2023
概括
有恶性潜力的口腔粘膜斑纹病 (OMPSD) 难以诊断. 直接免疫光 (DIF) 有助于差异诊断,纤维素和IgM可能是口腔平坦菌 (OLP) 的关键.
科学领域:
- 口腔病理学 口腔病理学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 口腔粘膜斑纹病 (OMPSD) 包括具有恶性潜力的疾病 (OMPSD-MP).
- 由于临床和病理特征重叠,OMPSD-MP的差异诊断是复杂的.
研究的目的:
- 分析和比较各种OMPSD-MP.的临床,组织病理和直接免疫光 (DIF) 特性.
- 评估DIF在区分OMPSD-MP中的实用性.
主要方法:
- 116名OMPSD-MP患者的横截面研究 (2019年11月 - 2021年2月).
- 包括口腔平坦状体 (OLP),口腔状体病变 (OLL), discoid 红斑狼 (DLE),口腔下粘膜纤维化 (OSF) 和口腔白血病 (OLK).
- 对一般信息,临床,遗传病理和DIF特征进行统计分析.
主要成果:
- 口腔平坦 (OLP) 是最常见的类型 (64.7%).
- 临床病理诊断一致性为OLP的73.5%和总OMPSD-MP的76.7%.
- 在OLP中,DIF阳性显著高于OLP (76.0%) 与非OLP (41.5%),OLP中经常检测到纤维素 (Fib) 和IgM.
结论:
- 在OMPSD-MP.的临床和组织病理特征中存在显著的重叠.
- 直接免疫光 (DIF) 是OMPSD-MP的差异诊断的一个有价值的工具.
- 纤维素素 (Fib) 和IgM可能在OLP的免疫病理学中发挥关键作用.
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