血calprotectin在患有 lysinuric 蛋白质不耐受症的患者中非常高
Mari Kärki1, Laura Tanner2,3, Satu Lahtinen4
1Department of Pediatrics University of Turku Turku Finland.
JIMD reports
|July 5, 2023
概括
素蛋白不耐受症 (LPI) 是一种罕见的遗传疾病. 芬兰LPI患者的血calprotectin水平极高,这表明LPI和免疫系统标记物之间存在联系.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- lysinuric蛋白不耐受 (LPI) 是一种罕见的自体倒退性疾病,影响了氨基酸的运输.
- 在LPI患者中之前已经观察到血含量升高.
- 结合蛋白质calprotectin在免疫功能中起作用.
研究的目的:
- 调查芬兰患者的血和calprotectin度,这些患者患有lysinuric蛋白质不耐受.
- 为了将这些水平与健康对照者的水平进行比较.
主要方法:
- 在10名LPI患者中,使用酶相关免疫吸收试验 (ELISA) 量化了血calprotectin.
- 血度通过光度测量进行测量.
- 对所有患者的淋巴膜过率进行了评估.
主要成果:
- 与健康对照组 (中位数:608μg/L) 相比,所有LPI患者的血calprotectin度显著高 (中位数:622,338μg/L).
- 血度正常或略高 (中位数:14.9μmol/L).
- 所有LPI患者都表现出球透率降低 (中位数:50毫升/分钟/1.73米2).
结论:
- 在Lysinuric蛋白不耐受症患者中观察到极高的血calprotectin度.
- 在LPI中这种高卡尔蛋白蛋白的潜在机制仍然是未知的.
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