StrainNet:通过DENSE的深度学习改进了Cine MRI的心肌应变分析
Yu Wang1, Changyu Sun1, Sona Ghadimi1
1From the Department of Biomedical Engineering, University of Virginia, Biomedical Engineering and Medical Science Building, Room 2013, MR5, Charlottesville, VA 22903 (Y.W., C.S., S.G., D.C.A., F.H.E.); Department of Biomedical, Biological and Chemical Engineering and Department of Radiology, University of Missouri, Columbia, Mo (C.S.); Department of Radiology, University Hospital of Saint Etienne, Saint Etienne, France (P.C.); CREATIS (UMR CNRS 5220, U1206 INSERM), INSA Lyon, Lyon, France (P.C., M.V.); BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (K.M., C.B.); Department of Translational Data Science and Informatics, Geisinger Health System, Danville, Pa (C.M.H., L.J., B.K.F.); Cardiovascular Research Center, University of Kentucky, Lexington, Ky (C.M.H., L.J., B.K.F.); The Heart Center, St Francis Hospital, Roslyn, NY (J.J.C., J.C.); Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, England (A.D.S., P.F.F.); Department of Radiology & Imaging Sciences and Biomedical Engineering, Emory University, Atlanta, Ga (J.N.O.); Department of Radiology, Stanford University, Stanford, Calif (D.B.E.); Department of Medicine (K.C.B.) and Department of Radiology and Medical Imaging (F.H.E.), University of Virginia Health System, Charlottesville, Va.
一个新的深度学习模型,StrainNet,使用cine MRI准确分析心脏应变,优于传统的特征跟踪方法. 这一进步改善了心脏成像中的心肌内位移和应变 (Ecc) 评估.
科学领域:
- 心血管成像 - 心血管成像
- 人工智能在医学中的应用
- 医学图像分析 医学图像分析
背景情况:
- 心脏MRI对于诊断心脏病至关重要,但准确的应变分析仍然具有挑战性.
- 现有的方法测量心肌张力从电影MRI有限制的精度和协议与参考标准.
研究的目的:
- 开发和评估一种新的三维卷积神经网络 (StrainNet),用于心内位移和应变分析.
- 训练StrainNet使用移位编码与刺激回声 (DENSE) 数据,并评估其在电影MRI上的性能.
主要方法:
- 使用心脏病患者和健康对照者的DENSE MRI数据开发了一个深度学习模型 (StrainNet).
- 该模型在心肌轮和DENSE位移测量上进行了训练,然后在电影MRI轮运动上进行了测试.
- 通过比较StrainNet衍生的全球和细分环形菌株 (Ecc) 与DENSE参考数据和商业特征跟踪 (FT) 使用各种统计方法来评估性能.
主要成果:
- 斯特林网在肌内心位移方面与DENSE表现出良好的一致性 (平均EPE为0.75mm±0.35).
- 在全球Ecc (ICC: 0.87) 和细分Ecc (ICC: 0.75) 方面,StrainNet与DENSE在FT (ICC分别为0.72和0.48) 相比显示出更好的协议.
- 布兰德-阿尔特曼分析证实StrainNet与DENSE在全球和细分Ecc方面比FT更好地达成一致.
结论:
- 在电影MRI中,StrainNet显著优于全球和细分Ecc分析的特征跟踪.
- 这种深度学习方法为评估心脏应变提供了更准确,更可靠的方法.
- 斯特莱恩网有望提高心血管成像诊断能力,包括儿科病例.
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