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Updated: Jul 24, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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5,6-不被替代的1,4-二皮里丁在Huisgen的1,4-二倍体循环添加和形式的 [2 + 2] 循环添加中的独特反应性

Xiu-Yu Chen1, Hui Zheng1, Ying Han1

  • 1College of Chemistry & Chemical Engineering, Yangzhou University, Jiangsu, Yangzhou 225002, China.

Beilstein journal of organic chemistry
|July 5, 2023
PubMed
概括

这项研究详细介绍了异类素和二类素的新反应. 新的化异环化合物,伊索奎诺林[1,2-f][1,6]纳二和阿扎比环[4.2.0]八二烯,被高效合成.

关键词:
1,4-二二二二二二二二二二惠斯根的1,4-二极管是吸收电子的阿尔基因.正式的 [2 + 2] 循环加法.这种类型的氨基酸是isoquinoline.异诺[1,2-f][1,6]纳二氨酸

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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