长期COVID的流行情况的系统审查
Mirembe Woodrow1, Charles Carey2, Nida Ziauddeen1,3
1School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Open forum infectious diseases
|July 5, 2023
概括
长期COVID影响了许多SARS-CoV-2感染后的个体,患病率因症状的测量方式而异. 即使是保守的估计也表明,这些持续的症状给全球的健康带来了相当大的负担.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 长期COVID的特点是严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染后持续或出现新的症状,这是一个日益严重的全球健康问题.
- 了解长期COVID的流行程度对于资源分配和公共卫生规划至关重要.
研究的目的:
- 在SARS-CoV-2感染后至少12周的成人和儿童中,系统地审查和确定持续症状,功能障碍或病理变化的患病率.
- 分析影响流行率估计的因素,如测量方法和研究人口.
主要方法:
- 对2020年1月1日至2021年11月2日期间发表的研究进行了系统审查.
- 研究包括至少100名参与者,用英语进行,并排除了那些只涉及重症患者的研究.
- 在12周或之后长期COVID症状或病理的患病率数据被提取并分析异质性.
主要成果:
- 包括120项研究,随访期从12周到12个月不等.
- 持久性症状的患病率差异很大 (0% - 93%),综合估计为42.1%.
- 使用自我报告的研究显示,与常规医疗记录 (13.6%) 相比,患病率更高 (43.9%),而系统病理学调查则产生了最高估计 (51.7%). 住院病例报告的患病率高于社区研究.
结论:
- 定义和测量方法显著影响长期COVID流行率估计.
- 由于SARS-CoV-2感染的广泛性质,预计全球慢性病的负担将会很大,即使有保守的流行率数据.
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