通过膀水分扩张成功治疗与免疫相关的囊炎
Tsutomu Anraku1,2, Hideki Hashidate3, Tomoyuki Imai1
1Department of Urology Niigata City General Hospital Niigata Japan.
IJU case reports
|July 5, 2023
概括
免疫检查点抑制剂可能会导致罕见的副作用,如囊炎. 膀水分扩张成功地治疗了患者的免疫相关囊炎,避免了类固醇使用和对癌症治疗的潜在影响.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 免疫检查点抑制剂 (ICI) 在晚期癌症治疗中至关重要,但可以诱导与免疫相关的不良事件 (irAEs).
- 随着ICI使用的扩大,越来越多的人报告罕见的irAEs.
- 免疫相关囊炎是一种潜在的影响尿路的irAE.
研究的目的:
- 在接受 pembrolizumab 治疗的患者中报告免疫相关囊炎病例.
- 评估膀液张作为ICI诱导囊炎的治疗方法的疗效.
- 探索一种替代类固醇治疗的替代方法,以保持IRES的ICI疗效.
主要方法:
- 一名70岁的男性患有晚期唾液管癌,接受了pembrolizumab.
- 患者在服用两剂pembrolizumab后出现了暗示囊炎的症状.
- 进行了诊断性膀活检和治疗性膀水分扩张.
主要成果:
- 组织学分析证实了非新发性膀粘膜与CD8阳性淋巴细胞透,表明与免疫有关的囊炎.
- 在膀水分扩张后,患者的尿路症状显著改善.
- 不需要使用类固醇,患者没有进一步的ICI相关并发症.
结论:
- 膀液张是免疫相关囊炎的可行和有效治疗方法.
- 这种程序为管理irAEs提供了一个类固醇节约的选择.
- 避免使用类固醇可能会保持免疫检查点抑制剂的抗癌效果.
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