在大鼠中,Onosma hispidum L. 提取物可逆转高脂血症,高血压和相关的血管功能障碍
Nadeem Ullah Wazir1, Irfan Amir Khan1, Adil Javed1
1Cardiovascular Research Group, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan.
Saudi journal of biological sciences
|July 5, 2023
概括
甲醇根提取物Onosma hispidum有效降低胆固醇和甘油三在超脂性大鼠. 这种天然疗法还可以改善血管功能,降低血压,表明其治疗潜力.
科学领域:
- 药理学和植物化学
- 心血管研究研究心血管研究
- 自然产品治疗药物 自然产品治疗药物
背景情况:
- 超脂血是心血管疾病的重要危险因素.
- 皮 (O. hispidum) 已经显示出管理高脂血症的初步潜力.
- 血管功能障碍是与高脂血症相关的常见并发症.
研究的目的:
- 评估O.hispidum甲醇根提取物在治疗高脂血症中的疗效.
- 评估O.hispidum提取物对相关血管功能障碍的影响.
- 调查潜在的机制,包括HMG-CoA减少酶抑制.
主要方法:
- 在Sprague-Dawley大鼠中诱导高脂血症使用tylloxopol和高脂肪饮食.
- 口服O.hispidum原油提取物 (O.hispidum原油提取物) 的使用 在不同的剂量.
- 生物化学分析脂质特征,HMG-CoA减少酶活性和血压测量.
- 动脉动脉组织的组织病理学检查和体外血管反应性研究使用隔离的老鼠大动脉环.
主要成果:
- ,这是一个很好的机会. 在超脂血性大鼠中,Cr显著降低了总胆固醇和甘油三 (p < 0.001).
- 提取物降低了体重和动脉质指数,并抑制了HMG-CoA减少酶的活性.
- 组织病理学显示大动脉形态和内皮功能有所改善;体外研究显示有显著的血管扩张.
- ,这是一个很好的机会. 在超脂血性高血压大鼠中,Cr还降低了平均动脉压.
结论:
- 甲醇基的O.hispidum根提取物显示出显著的抗高脂效应.
- O.hispidum提取物可以改善血管内皮功能,降低血压.
- 观察到的效应部分归因于HMG-CoA减少酶抑制,将O.hispidum定位为心血管健康的潜在治疗剂.
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