肠道微生物组失调与挪威Lundehund的宿主遗传学有关
Claudia Melis1, Anna Maria Billing1, Per-Arvid Wold1
1Department of Nature, Environment and Health, Queen Maud University College, Trondheim, Norway.
Frontiers in microbiology
|July 5, 2023
概括
主体遗传学显著影响挪威伦德汉德犬的肠道微生物组组成. 纯种伦德汉德犬表现出与伦德汉德综合征相关的微生物组失调,与外交代不同.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 遗传学 是一个遗传学.
- 微生物学 微生物学
背景情况:
- 微生物组失调,一种异常的肠道细菌组成,与各种疾病有关.
- 主体遗传学是影响肠道微生物组合的已知因素.
- 挪威伦德亨德犬品种患有蛋白质损失肠病 (伦德亨德综合征) 的高发病率.
研究的目的:
- 调查挪威伦德犬宿主遗传背景与肠道微生物组组成之间的关联.
- 评估通过外交引入的遗传多样性是否会影响微生物组的组成,并可能减轻隆德汉德综合征.
主要方法:
- 从75只跨越父母 (Lundehund) 和外交 (F1,F2) 代的狗身上收集了便样本.
- 分析了肠道微生物组的组成,以确定几代人之间的差异.
- 评估了环境因素 (饮食,家庭,益生菌) 对微生物群的影响.
主要成果:
- 在纯种伦敦犬和外交后代之间观察到肠道微生物组合的显著差异.
- 纯种伦德汉德犬表现出微生物组失调,其特点是 Firmicutes/Bacteroidetes比率升高和 *Streptococcus bovis/equinus* 复合体增加.
- 在这项研究中,环境因素对微生物组的组成或多样性没有显著影响.
结论:
- 在挪威伦德犬中,宿主遗传和肠道微生物组组成之间存在强烈的关联.
- 在纯种伦敦犬中观察到的失生症可能导致伦敦综合征的高发病率.
- 通过外交的遗传多样性可能会对这种品种的肠道微生物群健康产生积极影响.
关键词:
Streptococcus equinus-infantarius-lutetiensis 这种类型的细菌是家养的狗是家养的狗.这种疾病叫做dysbiosis.遗传多样性 遗传多样性我们的肠道微生物组.跨越越过的越来越多.更多相关视频
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