用双边肺密封剂治疗的严重肺:一个长期随访的病例系列
Cecilia Lindnér1, Kristine Jensen2, Jann Mortensen3,4
1Department of Thoracic and Cardiovascular Surgery, Heart Center, Copenhagen, Denmark.
Biomedicine hub
|July 5, 2023
概括
肺膜密封剂 (ELS) 为肺提供支气管镜肺体积减小,改善肺功能和症状长达五年. 然而,它没有证明生存益处,需要进一步研究患者选择.
科学领域:
- 肺部病理学 肺部病理学
- 干预性肺病学 干预性肺病学
- 生物材料在医学中的应用
背景情况:
- 支气管镜肺体积减小 (BLVR) 是治疗肺气的手术肺体积减小 (LVRS) 的一种不断发展的替代方案.
- 肺膜密封剂 (ELS) 针对具有附带通风 (CV) 的患者,显示改善肺功能的希望.
- 之前的研究表明,ELS在长达两年的时间内获得了良好的结果.
研究的目的:
- 介绍一系列病例,包括四名双边接受ELS治疗的肺气患者.
- 评估ELS长期疗效和安全性,治疗后长达6年.
- 评估肺功能变化,主观症状和患者结果.
主要方法:
- 四名患有肺气的患者接受了双边ELS治疗.
- 两名患者之前有LVRS和BLVR与门.
- 随访时间延长至6年,包括螺旋计和COPD评估测试 (CAT) 成绩.
主要成果:
- 所有患者在ELS后表现出改善的螺旋计值,持续时间从一年到五年不等.
- 三名患者报告主观症状改善 (CAT分数),其中一名患者经历了超过五年的持久益处.
- 两名患者经历了反复的恶化和肺炎,需要在一年和三年内进行肺移植.
结论:
- 在肺瘤患者中,ELS有效降低了高通胀,并改善了肺功能和呼吸障碍症状,长达五年.
- 可能会出现复发症,如反复恶化,可能导致肺移植.
- 需要进一步的研究来确定ELS的最佳候选人,并有效地管理CV阳性患者.
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