周围脂肪厚度与2型糖尿病中代谢功能障碍相关的脂肪肝疾病有关
Jian Yang1, Chuan Wang Li1, Jing Ru Zhang1
1Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, 364000, People's Republic of China.
概括
周周脂肪厚 (PrFT) 与2型糖尿病中代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有关. 增加PrFT与MAFLD和肝纤维化有关,这表明它可能是内脏脂肪区域的替代标记物.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 放射学 放射学是一门学科.
背景情况:
- 周周脂肪组织 (PAT) 在代谢疾病中起作用.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是2型糖尿病 (T2DM) 的一个日益关注的问题.
研究的目的:
- 评估T2DM患者周围脂肪厚度 (PrFT) 和MAFLD之间的关联.
- 评估PrFT作为MAFLD和肝纤维化的潜在生物标志物.
主要方法:
- 867名T2DM参与者接受了人体测量和生物化学测量.
- MAFLD诊断遵循了国际专家的共识.
- 使用计算机断层扫描和生物电阻分析评估了PrFT,脂肪肝,内脏脂肪区域 (VFA) 和皮下脂肪区域 (SFA).
- 非酒精性脂肪肝纤维化得分 (NFS) 和纤维化-4 (FIB-4) 指数用于评估肝纤维化.
主要成果:
- 在T2DM队列中,MAFLD的患病率为62.3%.
- 在MAFLD患者中,PrFT显著高于MAFLD患者,与代谢因素和肝纤维化指数 (NFS,FIB-4) 相相关.
- PrFT显示出与MAFLD的强烈关联,独立于VFA和SFA,曲线下的面积为0.782,表明与VFA相比的诊断值.
结论:
- 周周脂肪厚 (PrFT) 在T2DM中独立与MAFLD和肝纤维化有关.
- PrFT是MAFLD的一个有价值的指标,与VFA相似.
- 在临床实践中,PrFT可作为另一种成像生物标志物用于识别MAFLD.
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