在非控制性喘,伴随性疾病和成人喘中的生物标志物之间的关联中,与年龄相关的差异
Katja Warm1, Linnea Hedman2, Caroline Stridsman1
1The OLIN Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
概括
在成人发作的喘中,并发症与老年人的控制不良有很强的联系. 临床生物标志物如中性粒细胞和乙氨基粒细胞与中年个体的失控喘有关.
科学领域:
- 肺部病理学 肺部病理学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 成人发作的喘是一种异质的疾病,通常与喘控制不良有关.
- 了解影响中年和老年人喘控制的因素至关重要,但有限.
- 伴随性疾病和临床生物标志物可能在成人喘管理中发挥重要作用.
研究的目的:
- 研究中年和老年人临床生物标志物,并发症和失控喘之间的关联.
- 根据年龄组区分与不受控制的喘相关的因素.
主要方法:
- 研究了一组基于人口的227名患有成人发作喘的成年人.
- 收集的数据包括临床检查,喘控制测试 (ACT),螺旋测量,皮肤刺伤测试,血液采样和部分呼出的氧化 (FeNO).
- 分析按年龄分层:中年 (37-64岁) 和老年 (≥65岁).
主要成果:
- 在双变种分析中,不受控制的喘 (ACT ≤19) 与较高的血中微粒细胞数量,肥胖 (BMI ≥30) 和并发症有关.
- 在多变量分析中,不受控制的喘与中性粒细胞≥5/μl (或2.35) 相关.
- 中年成年人显示,BMI≥30,乙酸蛋白≥0.3/μl,中性酸蛋白≥5/μl和过敏性鼻炎的相关性.
- 老年人患有无法控制的喘,与慢性鼻炎,缺血性心脏病,恶性瘤和抑郁症/焦虑症有关.
结论:
- 在老年人群中,并发症与未经控制的成人发作的喘密切相关.
- 临床生物标志物,包括血液中乙酸氨基和中性酸氨基,与中年成年人的失控喘有关.
- 年龄特异性因素影响喘控制,突出需要量身定制的管理策略.
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