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确定旋转型血小板造影仪的儿科参考范围.

Erin Kathleen Goodhue Meyer1, Joshua Uffman2, Stephanie Townsend1

  • 1Department of Pathology and Lab Medicine, Transfusion Service, Nationwide Children's Hospital, Columbus, OH, USA.

American journal of clinical pathology
|July 5, 2023
PubMed
概括

这项研究确定了在儿童中进行旋转血栓弹性质计 (ROTEM) 达尔塔试验的正常儿科参考间隔. 这些新的特定年龄范围有助于临床医生为儿科患者做出明智的输血决定.

关键词:
凝血是凝固的过程.儿科 儿科 儿科旋转性血栓弹性测量 (Thromboelastometry) 是一种旋转式血栓弹性测量.输血 输血 输血 输血

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科学领域:

  • 儿科血液学 儿科血液学
  • 血液静止和血栓形成
  • 临床病理学 临床病理学

背景情况:

  • 在儿童中精确解释旋转性血栓形成显微镜 (ROTEM) 德尔塔测定需要特定年龄的参考间隔.
  • 现有的参考范围通常基于成人数据,这可能导致儿科患者误解.

研究的目的:

  • 为ROTEM Delta测定 (EXTEM,INTEM,FIBTEM) 建立正常的儿科参考间隔 (PRI).
  • 涵盖从0到18岁的广泛的儿科年龄范围.
  • 为了方便对儿童的凝血状况进行准确的解释.

主要方法:

  • 一项前性研究,涉及健康的儿科患者接受选择性轻微手术.
  • 在5个年龄组中,按性别抽取了20名患者 (0-6个月,6-12个月,1-5岁,5-11岁,11-18岁).
  • 进行了ROTEM Delta测定 (EXTEM,INTEM,FIBTEM) 的测试.

主要成果:

  • 定义了两组ROTEM PRI:一个是11岁以下的儿童,另一个是11岁以上的儿童.
  • 小孩子的PRI来源于0-11岁年龄组的2.5分和97.5分百分位.
  • 对于11岁以上的儿童,成人参考间隔得到了验证.

结论:

  • 为儿科患者建立了特定年龄的ROTEM PRI.
  • 将这些PRI整合到电子病历中,供临床使用.
  • 改进了ROTEM结果的解释,并对儿童的输血决策作出了明智的决定.