用修改的QuEChERS方法与GC/MS和GC/MS/MS进行地虫中多基碳醇和两个相关化合物的分析
Chaojie Li1, Qi Su1, Juan Wu1
1College of Environment, Zhejiang University of Technology, Hangzhou, 310014, China.
概括
一种基于QuEChERS的新分析方法可以准确地确定无脊椎动物中的多碳醇 (PHCZ) 和相关化合物. 这种经过验证的方法为环境和毒理学研究提供了可靠的常规分析.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 多碳醇 (PHCZ) 是一种持久性有机污染物.
- 在生物矩阵中精确量化PHCZ对于风险评估至关重要.
- 现有的分析方法可能缺乏全面分析的敏感性或范围.
研究的目的:
- 开发和验证一种精确的分析方法,用于同时确定11个PHCZ,碳醇 (BZCZ) 和9H碳醇 (CZ).
- 建立一种可靠的工具,用于在无脊椎动物中常规分析PHCZ同源.
主要方法:
- 使用了快速,简单,廉价,有效,坚固和安全 (QuEChERS) 的样本准备技术.
- 采用气体染色学与三重四极联质谱学 (GC-MS/MS) 和气体染色学-质谱学 (GC-MS) 结合用于量化.
- 验证了线性,检测和量化极限 (LOD/LOQ,MLD/MLQ),矩阵效应,准确性和精度的方法.
主要成果:
- 在0.005-0.2μg/mL范围内的所有目标化合物实现了良好的线性 (R2 > 0.992).
- 在大多数分析样品中,证明了令人满意的恢复率 (71.21105.04%) 和精度 (RSD <10.46%).
- 报告的低仪器LOD/LOQ (0.050.24 ng/0.140.92 ng) 和方法MLD/MLQ (0.020.12 ng/g ww/0.070.45 ng/g ww).
结论:
- 开发的基于QuEChERS的GC-MS/MS方法对于同时确定PHCZ,BZCZ和CZ的准确和准确.
- 该方法具有出色的性能特征,使其适合在无脊椎动物物种中对这些污染物的常规分析.
- 这种分析方法支持环境监测和涉及碳醇衍生物的毒理学研究.
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