调查国家教育计划对患者对骨质疏松症药物的坚持的影响
Thu Vuong1, Matthew Peters2, Alistair Merrifield2
1NPS MedicineWise, Level 7, 418A Elizabeth Street, Surry Hills, NSW, 2010, Australia. huongthuhanoi@gmail.com.
Archives of osteoporosis
|July 5, 2023
概括
全国骨质疏松教育计划在澳大利亚显著改善了药物坚持. 该计划增加了坚持骨质疏松症治疗的患者比例,尽管denosumab的坚持仍然不理想.
科学领域:
- 药物经济学和卫生政策
- 公共卫生干预措施 公共卫生干预措施
- 药物坚持研究 药物坚持研究
背景情况:
- 骨质疏松症药物不服药构成了重大的公共卫生挑战,增加骨折风险.
- 该NPS MedicineWise计划旨在通过澳大利亚的全科医生进行大规模,基于证据的教育干预来提高骨质疏松症药物的坚持.
研究的目的:
- 评估国家NPS MedicineWise骨质疏松症计划对药物坚持的影响.
- 在计划实施前和之后评估骨质疏松症治疗坚持率的变化.
主要方法:
- 使用中断时间序列 (ITS) 分析进行的回顾性观察研究.
- 对2011年12月至2019年12月期间45岁及以上的71,093名患者的制药福利计划 (PBS) 发行数据的分析.
- 通过覆盖日数比例 (PDC) ≥80%的患者的比例来衡量坚持.
主要成果:
- 该计划显著提高了整体骨质疏松症药物坚持.
- 坚持率从没有计划的估计43.5%增加到计划后12个月的48.4%.
- 虽然遵守情况有所改善,但12个月后仅用德诺苏马布 (denosumab) 的处方率仍未达到最佳水平,为65.0%.
结论:
- 通过影响处方者的行为,NPS MedicineWise计划有效地改善了骨质疏松症药物坚持.
- 尽管有所改善,但某些药物如登苏马布 (denosumab) 的非最佳守程度突显了针对性干预措施的必要性.
- 建议采取进一步的战略,重点关注长期坚持和管理治疗中止,以优化澳大利亚的骨质疏松症护理.
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