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Updated: Jul 24, 2025

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用牛免疫接种与酵母表面显示相结合的抗原特异性非传统牛超长CDR3H抗体的隔离

Paul Arras1, Jasmin Zimmermann1,2, Britta Lipinski1,2

  • 1Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.

Methods in molecular biology (Clifton, N.J.)
|July 5, 2023
PubMed
概括

牛抗体具有独特的超长CDR3H区域,用于新型表位体识别. 一种新的高通量酵母显示方法可以有效地隔离这些强大的牛抗体.

关键词:
抗体显示显示器显示抗体.抗体工程是一种抗体工程.牛的超长CDR3H抗体.一个的旋.酵母表面显示显示器 酵母表面显示器

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相关概念视频

Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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