与大脑洞腔形相关,通过立体性放射性手术管理:一项国际多中心研究
Chloe Dumot1,2, Georgios Mantziaris1, Stylianos Pikis1,3
1Department of Neurological Surgery, University of Virginia, 1215 Lee St, Charlottesville, VA, 22908, USA.
Journal of neurology
|July 5, 2023
概括
立体辐射手术 (SRS) 提供了对脑洞性形 (CCM) 的控制. 几乎一半的患者在单独的CCM治疗SRS后实现了无发作 (恩格尔I类).
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 立体射线外科手术 (SRS) 是治疗的替代方案,用于治疗脑洞性形 (CCM) 在关键脑部区域的患者.
- 大脑洞穴性形会导致衰弱性发作,影响生活质量.
研究的目的:
- 评估SRS在控制单独CCM患者的发作中的有效性.
- 确定影响控制结果的因素,在SRS后用于CCM.
主要方法:
- 多中心,回顾性研究设计.
- 包括109名患有单独CCM和先前的患者.
- 使用恩格尔分类对控制的评估,SRS后的中位数随访时间为3.5年.
主要成果:
- 47.7%的患者实现了恩格尔I类 (无) 结局.
- 在和SRS呈现之间延迟超过1.5年与较低的发作自由概率 (HR 0.25) 相关.
- 在耐药性患者中,22.2%的患者在SRS后实现了恩格尔I类结局.
结论:
- 在一些单独的CCM患者中,SRS是控制发作的有效治疗选择.
- 及时对SRS进行干预可能会改善控制结果.
- 进一步的研究是有必要的,以优化SRS治疗协议的CCM相关的.
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