代谢操纵和治疗性低温症
Katharyn L Flickinger1, Alexandra Weissman1, Jonathan Elmer1,2
1Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Therapeutic hypothermia and temperature management
|July 5, 2023
概括
这项研究表明,通过氧气消耗 (VO2) 测量的人类新陈代谢率,随着核心身体的冷却显著下降. 这种减少约为每摄氏度5.2%,突出显示了温度调节的作用.
科学领域:
- 身体生理学 身体生理学
- 热调节 热调节 热调节
- 代谢速率 代谢速率 代谢速率
背景情况:
- 低温会引起生理变化,包括降低代谢率和氧气消耗 (VO2).
- 关于核心温度降低和VO2变化之间的确切关系,人类数据有限.
研究的目的:
- 要量化休息VO2的减少,因为核心体温在轻度镇静的健康个体下降.
- 在受控的人类模型中建立核心温度和代谢率之间的关系.
主要方法:
- 参与者使用静脉冷液和表面冷却进行冷却.
- 使用德克斯梅德托米丁可以抑制发.
- 休息VO2通过间接热量计在37°C,36°C,35°C,34°C和33°C的核心温度下测量.
主要成果:
- 休息VO2随着核心温度的下降而下降,在没有发的情况下,从37°C降至33°C,平均下降20.8%.
- 每摄氏度VO2中最显著的平均降低为13.7%,发生在37°C和36°C之间.
- 发的开始阻止了进一步的温度下降,并导致VO2的增加.
结论:
- 在轻度镇静的人类中,每1°C内心温度从37°C下降到33°C,新陈代谢率下降约5.2%.
- 在37°C和36°C之间显著的代谢率下降表明,在这些温度下,潜在的亚临床或其他同位素反应.
相关概念视频
Homeostatic Imbalances in Body Temperature
158
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
158
Decreased Body Temperature
654
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
654
Thermoregulation
1.1K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.1K
Regulation of Metabolism
9.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.5K
Methods of reducing fever
706
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
706


