富可桑丁对代谢综合征,胰岛素敏感性和胰岛素分泌的影响
Armando López-Ramos1, Manuel González-Ortiz1,2, Esperanza Martínez-Abundis1,2
1Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Science University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Journal of medicinal food
|July 5, 2023
概括
富可丁补充剂显著改善了代谢综合征成分,减少体重,BMI,腰围,血压和甘油三. 它还增强了代谢综合征患者的胰岛素敏感性和分泌.
科学领域:
- 营养科学和代谢健康研究.
- 对代谢障碍的自然化合物的临床研究.
背景情况:
- 代谢综合征 (MetS) 是一组疾病,增加患心脏病,中风和2型糖尿病的风险.
- 胰岛素抵抗和胰岛素分泌受损是MetS的关键特征.
- 富可丁是一种海洋类胡卜素,在临床前研究中显示出潜在的抗肥胖和抗糖尿病作用.
研究的目的:
- 评估富可桑补充剂在改善代谢综合征 (MetS) 参数方面的疗效.
- 评估福可桑丁对 MetS 患者胰岛素敏感性和胰岛素分泌的影响.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验,涉及28名被诊断患有MetS的患者.
- 参与者每天接受12毫克的富可桑或安慰剂.
- 代谢参数,胰岛素敏感性 (马苏达指数) 和胰岛素分泌 (Stumvoll指数,总分泌) 通过干预前后2小时的口服葡萄糖耐受性测试进行测量.
主要成果:
- 富可丁显著降低了体重 (BW),体重指数 (BMI),腰围 (WC),静脉血压 (SBP),腹血压 (DBP) 和甘油三 (TG).
- 在胰岛素分泌的第一阶段 (Stumvoll指数) 和总胰岛素分泌中观察到改善.
- 在BW,BMI,WC,SBP,DBP,TG,Stumvoll指数和总胰岛素分泌量 (P < .05对所有人) 中发现了特定的显著变化.
结论:
- 富可丁补充剂有效地改善了代谢综合征的关键组成部分.
- 富可丁在患有MetS的患者中对胰岛素敏感性和分泌途径都有积极的影响.
- 这项研究支持fucoxanthin作为治疗代谢综合征的潜在治疗剂.
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