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净中性纳米粒子-挤出微囊用于口服输送胰岛素

Xiang Lu^1,2,3, Jing Li¹, Meng Xue¹

¹School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

ACS applied materials & interfaces

|July 5, 2023

概括

这项研究介绍了一种使用pH触发微囊的新型口服胰岛素输送系统. 该系统增强了胰岛素的生物可用性和血糖控制,为糖尿病管理提供了潜在的突破.

科学领域:

生物材料科学生物材料科学
药物运输药物运输药物运输
内分泌学在内分泌学.

背景情况:

口服胰岛素因肠道粘液屏障而面临挑战,限制了治疗疗效.
中性表面电荷粒子可以改善粘液的透,但它们的合成是复杂的.
野生花花粉提供了一个自然的,对pH响应的微囊平台.

研究的目的:

开发一种方便的方法来创建用于口服胰岛素输送的净中性颗粒 (NN).
在野生花花粉中封装NN,以创建pH触发的纳米颗粒-挤出微囊 (PNMs@胰岛素).
评估PNMs@胰岛素系统用于糖尿病治疗的生物可用性和有效性.

主要方法:

通过调整基托 (阳性) 和g-glutamic 酸 (阴性) 的比率,便于合成NN.
将NN封装到野生花花粉中,形成PNMs@insulin.
在体内评估血胰岛素水平和口服后血糖降低.

主要成果:

通过PNMs@insulin系统实现了高口服胰岛素生物利用率 (> 40%).
在糖尿病模型中证明了显著和持续的血糖降低.
识别出空的花粉作为潜在的糖吸附剂.

结论:

开发的PNMs@胰岛素系统提供了一种简单有效的胰岛素口服输送策略.
这种方法显著改善了胰岛素的生物可用性和血糖控制.
通过花粉吸附糖的双重功能增加了糖尿病管理的治疗价值.

关键词:

在这种情况下,胰岛素胰岛素胰岛素.这是肠道粘液.净中性的纳米粒子.花粉,花粉,花粉.它可以吸收糖.

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