甲状腺激素系统干扰不良结果途径网络的跨物种适用性
Ann-Cathrin Haigis1, Lucia Vergauwen1, Carlie A LaLone2
1Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
概括
本综述通过评估跨物种推断适用的分类学领域来提高对甲状腺激素系统干扰 (THSD) 的理解. 它提供了证据支持THSD对脊椎动物神经发育和生殖的影响.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 比较生物学的比较生物学
背景情况:
- 破坏甲状腺激素系统的化合物对人类和环境健康构成风险.
- 甲状腺激素系统干扰 (THSD) 的不良结果途径 (AOP) 正在跨种群开发.
- 对THSD进行跨物种AOP网络有助于数据推断,并弥合了人类和环境健康方面的担忧.
研究的目的:
- 在THSD AOP网络中增强分类应用领域 (tDOA).
- 提高网络的实用性,以便跨物种推断THSD数据.
- 评估分子发起事件 (MIE) 和不良结果 (AO) 的可信和经验应用领域.
主要方法:
- 专注于THSD AOP网络中的MIE和AO.
- 评估了可信的tDOA (税收适用性) 和经验的tDOA (适用性的证据).
- 审查了现有文献,以证实脊椎动物种群的结构性保护和功能相关性.
主要成果:
- 在AOP网络中的所有MIE都适用于哺乳动物.
- 证据表明THSD途径的结构性保护存在于脊椎动物中,特别是在鱼类和两动物中.
- 神经发育障碍,神经感官发育 (例如视力) 和生殖被支持为脊椎动物种类中适用的不良结果.
结论:
- 该研究推进了THSD AOP网络的tDOA描述.
- 提出了一个概念性的AOP网络,以优先考虑进一步的评估.
- 本综述作为未来跨物种AOP开发和tDOA评估的目录.
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