全基因组重复和长期进化基因调节网络在血管精子
Fabricio Almeida-Silva1,2, Yves Van de Peer1,2,3,4
1Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Molecular biology and evolution
|July 5, 2023
概括
全基因组重复 (WGD) 和小规模重复 (SSD) 塑造了植物基因组. WGDs影响调节网络和剂量敏感基因,而SSDs影响压力反应,影响血管精子进化.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 系统生物学 系统生物学
背景情况:
- 血管精子表现出复杂的全基因组重复 (WGD) 历史,影响基因组成和保留.
- 调节基因和多蛋白质复合体中的基因在WGDs之后优先保留.
- 了解WGD和小规模重复 (SSD) 对基因网络的影响对于植物进化至关重要.
研究的目的:
- 为了推断蛋白质-蛋白质相互作用 (PPI) 和基因调节网络 (GRNs) 七种种子.
- 通过检查网络动机频率来分析WGD和SSD对网络拓的影响.
- 探索基因保留和功能类别如何受到重复事件的影响.
主要方法:
- 七种种子种类的推断PPI和GRNs.
- 分析了网络图案频率,以评估WGD和SSD的影响.
- 在基于功能类别和剂量灵敏度的网络动机中比较WGD衍生和SSD衍生基因.
主要成果:
- 在剂量敏感系统中,PPI网络显示了WGD衍生基因的丰富,强大的选择限制了分歧.
- 基因中的WGD衍生基因与转录,细胞循环,翻译,光合作用和碳代谢有关.
- 基因中的SSD衍生基因与生物和非生物应激反应有关;最近的多倍体比古老的多倍体具有更高的基因频率.
结论:
- 无论是WGD还是SSD都对血管精子GRN进化有所贡献,但通过不同的机制.
- 显然,WGD事件对多体的进化有更实质性的短期影响.
- 长期的WGD影响可能导致网络动机的破坏,突出演化权衡.
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