儿童艾滋病毒的主要神经表现
Jane Jackie David1, Syed Ahmed Zaki2, Preeti Shanbag3
1Seth G.S. Medical College and KEM Hospital, Mumbai, India.
Journal of infection in developing countries
|July 5, 2023
概括
人类免疫缺陷病毒1型 (HIV-1) 感染儿童的神经并发症很常见. 本综述详细介绍了儿童的原发性艾滋病毒相关神经疾病,有助于理解和管理.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 人类免疫缺陷病毒1型 (HIV-1) 感染影响了各种年龄组,神经表现显著影响了发病率和死亡率.
- 曾经认为,HIV-1中中枢神经系统 (CNS) 的参与仅在晚期阶段才会发生,但现在的证据表明,从最初的感染开始就有病理性的参与.
- 艾滋病毒-1感染儿童的神经表现与成年人有相似之处,但也具有独特的方面,一些情况在一个人群中很少见,但在另一个人群中很常见.
研究的目的:
- 系统地审查有关艾滋病毒-1感染儿童初级神经系统疾病的表现,原因,结果和治疗的文献.
- 为儿童群体提供艾滋病毒相关的神经综合征的全面概述.
主要方法:
- 在线数据库 (Ovid Medline,Embase,PubMed),世卫组织网站,商业搜索引擎 (谷歌) 和相关教科书章节的系统审查.
- 专注于儿童艾滋病毒的主要神经表现.
主要成果:
- 与艾滋病毒相关的神经综合征被分为四种类型:原发性艾滋病毒神经疾病,与治疗相关的神经疾病,抗逆转录病毒疗法的不良神经效应以及二次/机会性神经疾病.
- 这些类别并不相互排斥,并且可以在一个患者中共存.
- 这篇评论特别关注儿童的主要神经学表现.
结论:
- 了解HIV-1在儿童中的不同神经表现对于有效管理至关重要.
- 该审查强调了认识到儿科和成人HIV-1患者之间共同和独特的神经方面的重要性.
- 持续的研究和全面的审查对于解决儿科艾滋病毒神经病学的不断变化的局面至关重要,尤其是改善的生存率.
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