ангиотензин转化酶 2 G8790A 多态性与COVID-19的严重程度有关
1Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Journal of infection in developing countries
|July 5, 2023
概括
ACE2 G8790A多态性与整体COVID-19风险没有联系. 然而,ACE2 G等位基因与亚洲人群的COVID-19严重程度增加有关,可能是由于ACE2转录水平较高.
科学领域:
- 遗传学和传染病的研究
- 分子生物学分子生物学
- 流行病学 流行病学
背景情况:
- 血管激素转化酶2 (ACE2) 蛋白质在防止严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 进入宿主细胞方面发挥着至关重要的作用.
- 之前的研究表明,ACE2 G8790A多态性和COVID-19风险之间存在联系,但这些发现没有确定性.
研究的目的:
- 进行元分析,准确评估ACE2 G8790A多态和COVID-19风险之间的关联.
- 调查这种协会中潜在的种族差异.
主要方法:
- 通过使用多个科学数据库 (PubMed,Embase,Cochrane Library,Scopus,Science Direct,Web of Science) 进行了相关文献的系统审查.
- 统计分析涉及计算几率比率 (OR) 和95%置信区间 (CI).
- 用STATA版本12.0.0进行了元分析.
主要成果:
- 整体元分析表明,ACE2 G8790A多态和COVID-19风险之间没有显著的关联.
- 根据种族分层的子组分析显示,ACE2 G等位基因与亚裔个体的COVID-19严重性风险增加有关.
- 针对各种遗传模型 (G与A,GG与AA,GA与AA,主导性,衰退性) 的特定OR表明亚洲人的风险显著增加.
结论:
- ACE2 G8790A多态性通常与COVID-19风险无关.
- ACE2 G8790A的G等位基因与亚洲人群中COVID-19严重程度的增加有关.
- 亚洲人中较高的ACE2转录水平和与细胞因子风暴的潜在联系可能解释了这种特定种族的关联,这表明在未来的疫苗开发中应该考虑遗传因素.
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