在 rhesus macaque 中关闭体的起源和发展
Hong Li1, Alvaro Duque2, Pasko Rakic1,2,3
1Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
概括
灵长类动物的关闭体从特定的胚胎起源发展,形成不同的层和细胞类型. 这项研究澄清了它的早期发展,并建议它.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 灵长类大脑研究研究
背景情况:
- 从动物研究中越来越多地认识到关闭体在注意力和认知中的作用.
- 关于灵长类动物关闭体的发展和起源的了解有限.
研究的目的:
- 为了研究 rhesus macaque claustrum 的胚胎起源和发育轨迹.
- 在发展中灵长类 claustrum 中描述早期分子标记物和神经发生模式.
主要方法:
- 对胚胎 rhesus macaque 大脑的分析.
- 分子标记物的免疫组织化学 (NR4A2,SATB2,SOX5,TBR1).
- 评估神经发生的时间和细胞类型 (帕瓦胺阳性内部神经元).
主要成果:
- 灵长类闭层神经元起源于E48-E55之间,表达新皮质标记物,但缺乏TBR1.
- 两个神经生成波建立了一个核心外结构,反映岛内皮层6和5.
- 帕瓦胺阳性内部神经元是主导的,并且独立于新皮质成熟.
结论:
- 灵长类动物的关闭体源于不同的发育起源,而不是作为岛屿亚板神经元的延伸.
- 它独特的细胞架构和细胞组成表明它在认知控制中起着专门的作用.
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