乳酸穿驱动烧伤后白色脂肪组织的色
Dalia Barayan1,2,3, Abdikarim Abdullahi1,2, Carly M Knuth1,2,3
1Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
概括
乳酸水平升高表明,烧伤后白色脂肪组织变棕,增加死亡率和肝脏功能障碍. 针对乳酸运输可以改善烧伤模型的结果.
科学领域:
- 生物化学 生物化学
- 代谢过程中的代谢.
- 生理学 生理学 生理学
背景情况:
- 高血乳酸与严重受伤患者的死亡率有关,包括烧伤患者.
- 乳酸酸会诱导白色脂肪组织 (WAT) 变色,这与后烧焦缓解症和超高代谢有关.
- 超乳酸血症和烧伤中WAT色之间的联系仍然不清楚.
研究的目的:
- 为了研究乳酸盐升高在中介性灼伤创伤后不良结果的因果作用.
- 为了确定乳酸信号是否直接促进燃烧后的WAT色.
- 探索乳酸,WAT棕色化和器官功能障碍之间的机械联系.
主要方法:
- 从人类烧伤患者和热损伤的小鼠模型中分析WAT.
- WAT色与乳酸进口和新陈代谢的相关性.
- 在体内给药l-乳酸盐和乳酸运输 (MCT) 的药理抑制.
- 评估死亡率,体重减轻,肝功能和WAT热生成.
主要成果:
- 燃烧后的WAT色与增加的乳酸进口和新陈代谢有积极的相关性.
- 在体内给予乳酸氨酸会加剧燃烧引起的死亡率,体重减轻和肝脏脂毒性.
- 乳酸诱导的WAT棕色化是由MCT载体,增加细胞内氧化还原压力和FGF21表达的介导.
- 在受烧伤的小鼠中,抑制MCT介导的乳酸摄取减弱了色,并改善了肝功能.
结论:
- 升高的乳酸在促进烧伤创伤后WAT色方面起着因果作用.
- 乳酸信号有助于燃烧后的高代谢,肝功能障碍和死亡率的增加.
- 向乳酸运输为管理烧伤并发症提供了潜在的治疗策略.
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