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在接受全身免疫抑制疗法的患者中选择性激光形术的有效性

Tyler M Kaplan¹, Jon D Hammer¹, Darrel Kohli¹

¹Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Journal of glaucoma

|July 5, 2023

概括

系统性免疫抑制疗法在选择性激光轨道造形术 (SLT) 后没有影响早期眼内压 (IOP) 降低. 然而,在接受免疫抑制治疗的患者中,SLT的IOP降低作用在1年后减弱.

科学领域:

眼科医生眼科眼科
青光眼治疗方法青光眼治疗方法
免疫学免疫学免疫学

背景情况:

选择性激光膜整形术 (SLT) 是一种常见的程序,用于降低青光眼患者的眼内压力 (IOP).
系统性免疫抑制疗法对SLT结局的影响尚不清楚.
了解这种相互作用对于在患有自身免疫或炎症性疾病的患者中治疗青光眼至关重要.

研究的目的:

为了比较SLT在接受全身免疫抑制药物治疗的患者与未接受此类治疗的患者的内脏压力降低功效.
评估免疫抑制个体对SLT的长期IOP反应.

主要方法:

一项回顾性研究比较了在2017-2021年期间接受SLT的患者.
患者被分为两组:接受全身免疫抑制疗法的患者和对照组.
主要终点包括在SLT后的1-2,3-6个月和12个月内内皮减少的百分比.

主要成果:

在SLT后1-2个月和3-6个月的组之间没有观察到IOP减少的显著差异.
在SLT后12个月,免疫抑制组的IOP降低明显小于对照组.
两组之间在需要额外的玻璃眼治疗方面没有发现差异.

结论:

系统性免疫抑制疗法不会损害SLT.的早期IOP降低效果.
在接受全身免疫抑制药物的患者中,对SLT的IOP降低反应在1年后减少.
需要进一步的研究来探索这种改变的长期反应背后的机制.

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