阳光候选菌的遗传学和出现
Anuradha Chowdhary1,2, Kusum Jain1, Neeraj Chauhan3
1Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India;
Annual review of microbiology
|July 5, 2023
概括
黄是一种多抗药性真菌,造成全球健康威胁. 本综述研究了它的传播,耐药性和基因组,以告知对抗这种新兴病原体的策略.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 黄是一种多药耐药的真菌病原体,在2009年被确定.
- 它已经在全球传播,导致高死亡率 (30-60%) 和医疗保健疫情.
- C. auris对所有主要的抗真菌药物类别都表现出耐药性,这构成了重大的临床挑战.
研究的目的:
- 探索Candida auris.在全球迅速传播的原因.
- 详细介绍C. auris的基因组组织和耐药性机制.
- 建议未来的研究方向,以控制C. auris的传播.
主要方法:
- 关于Candida auris的已发表研究的文献综述.
- 对基因组数据和耐药性概况的分析.
- 综合当前的知识和识别研究差距.
主要成果:
- 黄菌表现出高效的传播,特别是在医疗保健机构.
- 它具有显著的,往往无法治疗的抗阿醇,安福特瑞辛B和乙康丁的耐药性.
- 了解它的基因组对于破译耐药机制至关重要.
结论:
- 黄菌 (Candida auris) 由于其多药性耐药性和传染性,对全球健康构成严重且日益增长的威胁.
- 对其基因组和耐药机制的进一步研究对于开发有效的治疗方法和控制策略至关重要.
- 需要跨学科的努力来制这种有弹性的真菌病原体的传播.
相关概念视频
Gene Regulation in Microbial Communities: Quorum Sensing
43
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
43
Genome Size and the Evolution of New Genes
8.0K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.0K
Cystic Fibrosis: Pathogenesis
293
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
293
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K


