在一名受伤的士兵体内发现六种高度耐药的细菌,乌克兰
Emerging infectious diseases
|July 5, 2023
概括
在一名受伤的军人身上发现了包括Acinetobacter baumannii和Klebsiella pneumoniae在内的多种耐药细菌. 这些隔离物含有众多抗生素耐药性基因,这给治疗带来了重大挑战.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 抗生素耐药细菌的增加构成了全球健康威胁,特别是在临床环境中.
- 受伤的军人可能面临患上多种耐药生物 (MDRO) 的风险.
研究的目的:
- 来自受伤的服务人员的细菌分离物的抗生素耐药性概况和遗传决定因素的特征.
- 为了确定在分离物中存在的特定的碳烯酶和16S甲基转移酶基因.
主要方法:
- 进行了血液和监测培养.
- 使用标准微生物学技术识别了细菌分离物.
- 进行了抗生素敏感性测试.
- 进行了基因组分析,以检测抗生素耐药性基因,包括卡巴酶和16S甲基转移酶.
主要成果:
- 他们分离了Acinetobacter baumannii,Klebsiella pneumoniae,Enterococcus faecium和三个不同的Pseudomonas aeruginosa菌株.
- 所有的隔离物对大多数测试的抗生素都表现出不敏感性.
- 检测到了广泛的抗生素耐药性基因,包括blaIMP-1,blaNDM-1,blaOXA-23,blaOXA-48,blaOXA-72,armA和rmtB4.4等.
结论:
- 该研究在受伤的军人身上发现了广泛的耐药细菌,突出了MDROs在这个人群中的潜力.
- 多个碳烯酶和16S甲基转移酶基因的存在强调了复杂的抵抗机制.
- 这些发现强调需要采取警监测和感染控制措施,以防止多药耐药生物的传播.
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