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Updated: Jul 24, 2025

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
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A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

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一个最近控制的合成卡丁多巴胺载体重吸收抑制剂的结构-活性关系:α-Pyrrolidinohexiophenone (α-PHP)

Rachel A Davies1, Vy T Nguyen2, Jose M Eltit2

  • 1Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.

ACS chemical neuroscience
|July 5, 2023
PubMed
概括

像α-Pyrrolidinohexiophenone (α-PHP) 这样的合成甲基是强大的多巴胺转运体抑制剂. 这项研究探讨了α-PHP类似物的结构-活性关系,发现除了三甲基变体外,大多数选择性地阻断多巴胺再吸收.

关键词:
抑制了DAT的再吸收.抑制SERT的重新吸收.卡西诺类似物多巴胺运输体是多巴胺的运输体.滥用药物 滥用药物 滥用药物 滥用药物 滥用药物血清的传送器 血清的传送器α-PVP 的存在.

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