额头双侧白质微观结构与ADHD儿童工作记忆表现相关
Lillian M Dipnall1, Danah Hourani2, Simone Darling3
1School of Psychology, Deakin University, Geelong, Australia.
概括
患有注意力缺陷/多动障碍 (ADHD) 的儿童表现出较差的工作记忆和左上纵向囊II (SLF-II) 白质组织的减少. SLF-II卷调解了ADHD和工作记忆缺陷之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 放射学 放射学是一门学科.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种影响执行功能的神经发育障碍,特别是工作记忆.
- 上端纵长 (SLF) 对于神经类型儿童工作记忆的发展至关重要.
- 据假设,SLF中白质组织的减少是ADHD工作记忆缺陷的基础.
研究的目的:
- 调查SLF白质组织与ADHD儿童工作记忆之间的关联.
- 为了比较患有ADHD和对照儿童之间的SLF体积和表面纤维密度 (AFD).
主要方法:
- 扩散磁共振成像 (dMRI) 和受约束的基于球形解卷的曲谱学被用来分析SLF.
- 在64名患有多动症和多动症的儿童和58名对照儿童 (年龄为9-11岁) 中,使用计算机化空间n-back任务评估工作记忆.
- SLF分支机构的通道容量和AFD是双边量化的.
主要成果:
- 患有ADHD的儿童表现出较差的工作记忆性能,其特点是反应时间和可变性 (RT和RT-V) 增加.
- 与对照组相比,在ADHD儿童中观察到左侧SLF-II的体积和AFD较低.
- 左SLF-II体积显著介导了ADHD和工作记忆性能之间的关系.
结论:
- 这些发现突出了前端双相白质完整性,特别是左侧SLF-II在与ADHD相关的工作记忆障碍中的作用.
- 这项研究有助于了解ADHD执行功能缺陷的神经生物学基础.
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