血D因子与低度炎症,内皮功能障碍和心血管疾病有截面相关:马斯特里赫特研究
Shunxin Jin1, Simone J P M Eussen2, Casper G Schalkwijk1
1Department of Internal Medicine, CARIM School for Cardiovascular Diseases, the Netherlands.
Atherosclerosis
|July 5, 2023
概括
D因子通过炎症和内皮功能障碍与心血管疾病 (CVD) 相关,而不是直接动脉样硬化. 较高的D因子可能会使心血管疾病的进展恶化,特别是在非糖尿病患者中.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 补体系统,特别是替代途径,与血管损伤和心血管疾病 (CVD) 有关.
- D因子是激活替代补充路径的关键蛋白酶.
研究的目的:
- 调查血D因子度与心血管不良结果之间的关联.
- 探索D因子,炎症,内皮功能障碍和动脉样硬化标志物之间的关系.
主要方法:
- 研究了2947名参与者,测量了D因子,低度炎症 (LGI),内皮功能障碍 (ED),心动脉内膜介质厚度 (cIMT),脚-手臂指数 (ABI) 和心血管疾病患病率.
- 利用多重线性和逻辑回归,调整各种混因素.
- 进行了相互作用分析,特别是关于糖尿病状况.
主要成果:
- 血D因子与LGI,ED和流行心血管疾病有显著的关联.
- 在因子D和cIMT或ABI之间没有发现显著的关联.
- 与2型糖尿病 (T2D) 患者相比,D因子在非糖尿病患者中与ED的相关性更强.
- 在非糖尿病患者中,D因子与cIMT相反相关,但在T2D患者中没有.
结论:
- 血D因子独立地与LGI,ED和流行心血管疾病有关.
- D因子可能通过补体激活,炎症和内皮功能障碍而不是直接动脉样硬化,导致心血管疾病的进展.
- 在糖尿病患者和非糖尿病患者中,D因子与ED和cIMT的差异关联需要进一步研究.
相关概念视频
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
763
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
763
01:30Peripheral Artery Disease I: Introduction
10
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
10
01:26Coronary Artery Disease II: Pathophysiology
14
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
14
01:38Inflammation
53.9K
Overview
53.9K
01:30Atherosclerosis I: Introduction
11
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
11
01:30Coronary Artery Disease I: Introduction
25
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
25