红树林沉积物中的垂直分层抵抗体是由细菌多样性驱动的
Jiaxiong Zeng1, Yu Pan2, Ruiwen Hu1
1Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510006, China.
Journal of hazardous materials
|July 5, 2023
概括
细菌多样性,而不是环境因素,控制了红树林沉积物中的抗生素和金属耐药性基因. 较高的细菌多样性与较低的抗性基因丰度相关,突出显示生物多样性在自然环境中的作用.
科学领域:
- 环境微生物学环境微生物学
- 微生物群落的生态学
- 抵抗基因的生物地质化学
背景情况:
- 抗生素耐药性基因 (ARG) 和金属耐药性基因 (MRG) 由于人类活动而传播.
- 生物和非生物因素对天然红树林沉积物中ARG和MRG的影响仍然不太清楚.
研究的目的:
- 调查红树林沉积物中ARG和MRG的分布和多样性.
- 探索ARG,MRG和沉积物微生物组之间的关系.
- 确定驱动耐药基因垂直配置的关键因素.
主要方法:
- 在0-100厘米的红树林沉积物中分析ARG和MRG的丰度和多样性.
- 分析抗性基因和沉积物微生物组之间的关系.
- 评估与非生物因素 (如营养素和抗生素) 的相关性.
主要成果:
- 多药耐药性和多金属耐药性基因最为丰富,并且随着沉积物深度的增加而减少.
- 细菌多样性,而不是非生物因素,与ARG和MRG的丰度和多样性有显著的负相关.
- 不同的细菌宿主在更深层的低丰度层中携带了大多数耐药基因.
结论:
- 细菌多样性是控制红树林沉积物中ARG和MRG垂直分布的主要生物因素.
- 生物多样性在调节抗性基因动态方面发挥着至关重要的作用,特别是随着人类影响日益增加.
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