在NIR光敏感脂质体中进行Ce6和DOX的无干扰输送,用于协同的宫癌治疗
Jia Zhang1,2,3, Yibo Yang1,2,3, Yanting Gao1,2,3
1College of Environmental & Chemical Engineering, Yanshan University, Qinhuangdao, Hebei Province 066004, People's Republic of China.
Biomedical materials (Bristol, England)
|July 5, 2023
概括
这项研究开发了对光敏感的脂质体,可以同时提供化疗 (多克索鲁比) 和光动力疗法 (e6) 药物. 这种联合治疗有效地抑制了71.90%的瘤生长,并减少了副作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 联合癌症治疗比单一治疗提供了优势,但在药物输送和瘤细胞积累方面面临挑战.
- 药物在输送过程中的相互干扰和瘤细胞中无效的积累是联合癌症疗法的关键障碍.
研究的目的:
- 设计一种新的纳米药物输送系统,用于联合化疗和光动力疗法 (PDT).
- 克服药物干扰并改善瘤部位的药物积累,以提高抗癌疗效.
主要方法:
- 使用薄膜水化,开发出对光敏感的脂质体 (DOX-Ce6-Lip) 封装了多克索鲁比 (DOX) 和e6 (Ce6).
- 利用增强的透性和保留 (EPR) 效应,增加瘤中药物积累.
- 使用660nm近红外 (NIR) 激光照射触发了对刺激有反应的药物释放.
主要成果:
- DOX-Ce6-Lip在瘤部位显示药物度增加,对正常组织的毒性降低.
- 尼尔射线激光照射诱导了反应性氧物种 (ROS) 的产生,导致脂质体崩和同时释放DOX和Ce6.
- 通过联合化疗和PDT,通过71.90±3.14%的显著瘤生长抑制.
结论:
- 开发的DOX-Ce6-Lip系统为具有不同溶解度的药物提供了有效的输送方案.
- 这项研究提出了一种强大的联合抗瘤治疗方法,结合化疗和光动力学疗法.
- 纳米药物输送系统显示出用于先进癌症治疗策略的多功能潜力.
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