患有海湾战争疾病的退伍军人的荷尔蒙变化
Gursimrat Bhatti1, Audri Villalon1, Ruosha Li2
1Michael E. DeBakey VA Medical Center, Houston, TX, USA; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston, TX, USA.
Life sciences
|July 5, 2023
概括
海湾战争疾病 (GWI) 与较高的成人生长激素缺乏率 (AGHD) 有关. 增长激素替代疗法 (GHRT) 可能为受影响的退伍军人提供一种新的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 军事医学 军事医学
- 神经科学是一个神经科学.
背景情况:
- 海湾战争疾病 (GWI) 是一种复杂的,多系统的疾病,影响了老兵.
- 内分泌功能障碍可能导致GWI症状.
- 目前没有针对GWI的特定治疗方法.
研究的目的:
- 为了研究海湾战争退伍军人的荷尔蒙变化.
- 确定GWI和荷尔蒙失调之间的关系.
- 为了确定GWI的潜在治疗点.
主要方法:
- 在81名海湾战争退伍军人 (54名与GWI,27名对照) 的横截面病例控制研究中.
- 使用了问卷,神经精神病学评估和全面的激素测试.
- 包括针对成人生长激素缺乏症 (AGHD) 的葡萄糖激素刺激测试和针对上腺功能不足的ACTH刺激测试.
主要成果:
- GWI退伍军人报告生活质量降低,症状严重程度增加.
- 成人生长激素缺乏症 (AGHD) 在GWI退伍军人中 (35.3%) 与对照人群 (7.7%) 相比明显更为普遍.
- 在GWI退伍军人中观察到胰岛素样生长因子1 (IGF-1) 的水平降低.
结论:
- 成人生长激素缺乏症 (AGHD) 在患有GWI的退伍军人中明显更常见.
- 复合人体生长激素替代疗法 (GHRT) 显示出作为治疗GWI患者的承诺.
- 需要进行进一步的临床试验,以确认GHT对GWI的疗效.
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