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新生儿成长和脂肪研究 (GAINS):产前DHA补充方案的影响

Holly R Hull¹, Byron J Gajewski², Debra K Sullivan¹

¹Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, United States of America.

Contemporary clinical trials

|July 5, 2023

概括

产前补充多可萨赫萨酸 (DHA) 可能会保护后代免受与过度妊娠体重增加相关的过度脂肪增加. 这项研究调查了DHA.

科学领域:

围产期营养和后代的身体组成.
母亲健康和胎儿发育
预防肥胖的战略预防肥胖的策略

背景情况:

肥胖和中部脂肪量 (FM) 积累与增加的疾病,发病率和死亡率有关.
过度的孕期体重增加 (GWG) 在母亲增加胎儿脂肪积累,导致更高的后代FM一生.
孕产妇的多可萨赫萨酸 (DHA) 水平与较低的儿童后代FM有关,但在美国,孕产妇摄入足够的DHA并不常见.

研究的目的:

为了确定产前的DHA补充是否可以保护后代的身体成分免受过度的GWG的影响.
为了研究产前DHA对后代脂肪质量 (FM) 和24个月龄的FM分布的影响.
评估产前DHA对母体体重增加和后代肥胖之间的关系的改变.

主要方法:

从ADORE随机对照试验 (NCT02626299) 中出生的婴儿将被邀请.
母亲被随机分配到高 (1000毫克) 或低 (200毫克) 的每日产前DHA补充剂.
后代的身体组成和脂肪组织分布通过双能X射线吸收计测量在2周,6,12和24个月.
根据临床指导方针,母体GWG被分类为过度或不过度.

主要成果:

该部分是在研究完成后填写的.
数据分析将重点关注母体GWG,产前DHA剂量和后代身体组成结果之间的关系.
将使用统计方法来确定DHA的显著关联和潜在的保护作用.

结论:

这项研究将提供关于产前DHA在减轻过度GWG对后代肥胖的长期影响中的作用的关键见解.
调查结果可以为公众健康建议提供孕产妇DHA补充剂的信息,以改善婴儿和儿童的身体组成.
预防肥胖发展的有效策略,针对产前暴露,是非常必要的.

关键词:

脂肪组织的分布.身体组成身体组成达科萨赫克萨埃诺酸是什么?增长的增长增长的增长怀孕怀孕怀孕怀孕

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